Phytoglycogen Nanoparticle Delivery System for Inorganic Selenium Reduces Cytotoxicity without Impairing Selenium Bioavailability
نویسندگان
چکیده
منابع مشابه
Relative Bioavailability of Inorganic and Natural Selenium
Introduction Research efforts have identified groups of people with low selenium intakes and presumed selenium deficiency based on low blood selenium levels. Inhabitants of New Zealand [1], Finland [2], and China [3] often have low blood selenium. Individuals with therapeutic diets low in selenium [4], people undergoing parenteral administration [5] and alcoholics with cirrhosis [6] can also be...
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Although the essentiality of dietary Se for sheep has been known for decades, the chemical source and Se dosage for optimal health remain unclear. In the United States, the Food and Drug Administration (FDA) regulates Se supplementation, regardless of the source of Se, at 0.3 mg of Se/kg of diet (as fed), which is equivalent to 0.7 mg of Se/d or 4.9 mg of Se/wk per sheep. The objectives of this...
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Selenium is an essential trace element with growth-modulating properties. Decades of research clearly demonstrate that selenium compounds inhibit the growth of malignant cells in diverse experimental model systems. However, the growth-modulating and cytotoxic mechanisms are diverse and far from clear. Lately, a remarkable tumour selective cytotoxicity of selenium compounds has been shown, indic...
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This study determined the bioavailability of selenium (Se) from yellow peas and oats harvested from the high-Se soil of South Dakota, United States. The Se concentrations were 13.5 ± 0.2 and 2.5 ± 0.1 mg/kg (dry weight) for peas and oats, respectively. Male weanling Sprague-Dawley rats were depleted of Se by feeding them a 30% Torula yeast-based diet (4.1 μg Se/kg) for 56 days, and then they we...
متن کاملSelenium compounds are substrates for glutaredoxins: a novel pathway for selenium metabolism and a potential mechanism for selenium-mediated cytotoxicity.
The Grx (glutaredoxin) proteins are oxidoreductases with a central function in maintaining the redox balance within the cell. In the present study, we have explored the reactions between selenium compounds and the glutaredoxin system. Selenite, GS-Se-SG (selenodiglutathione) and selenocystine were all shown to be substrates of human Grx1, implying a novel role for the glutaredoxins in selenium ...
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ژورنال
عنوان ژورنال: International Journal of Nanomedicine
سال: 2020
ISSN: 1178-2013
DOI: 10.2147/ijn.s286948